This website uses cookies to give you the best experience. By continuing to use this website you are consenting to cookies being used. You can delete and block cookies from within your browsers settings. For more information please refer to our privacy and cookie policy page.


Multi-system Disease

Musculoskeletal features are common in multisystem disease - this can be true arthritis (usually affecting many joints in a symmetrical pattern) or arthralgia (painful joints without overt swelling) with or without myalgia (muscle pain) or myositis (muscle pain and tenderness, often with weakness). 

Systemic features may be present - malaise, fatigue, weight loss, fever, rash - and may relate to conditions such as connective tissue disease, for instance Juvenile Systemic Lupus Erythematosus, Juvenile Dermatomyositis, Vasculitis, Scleroderma, Periodic (Autoinflammatory) syndromes, although the differential diagnosis includes serious conditions such as infection and malignancy

There is also the possibility of chronic diseases that may develop musculoskeletal features and these include inflammatory bowel disease, metabolic conditions and genetic syndromes. 

Diagnosis rests on clinical assessment and careful use and interpretation of investigations. 

The photograph below shows skin vasculitis

 The photograph below shows severe ischaemic changes in a child with vasculitis - several toes were lost due to gangrene

Site Statistics

To date (end of November 2021) PMM has >968,551 hits and >402,983 users from 221 countries!

Why register?

Some parts of pmm which involve pictures or videos of children, can only be viewed by registered users. Registering also allows you to bookmark favourite pages and track your viewing.

find out more

Short online courses

from Newcastle University, UK

e-resources from PMM

pmm for you

Please help us ensure pmm is as useful to you as possible by completing this short survey

complete survey